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EnginePart report

2021 Ford E-350 Engine Problems

Complaints
11about this part
Share
50%of 22 total for the year
Median mileage
—not reported
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 11 complaints about the engine of the 2021 Ford E-350, 50% of the 22 complaints for this model year. 2 recall campaigns on record are filed under a similar system.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“Engine failure at 78,172, excess wear to the camshaft lobes and valve tappet surface. We have had 22 failures. There was a recall -24B27 for 2021 and 2022 models year for idle oil pressure. Most vans had 70 to 80k on them by the time we received a letter. Some engine have been changed twice. Ford has a serious problem and is not acknowledging it. Please help! Montachusett Regional Transit Authority , Fitchburg MA 01420”

NHTSA complaint #11701901, filed 2025-11

“This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.”

NHTSA complaint #11643142, filed 2025-02

“This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.”

NHTSA complaint #11643144, filed 2025-02

“This is one of 4 of my 2021 ford econoline fleet vehicles purchased in 2021 that have had engine failure. I am one of many contractors in my area and others around the country who have had this issue with the same F59 engine. Ford has failed to issue a recall.”

NHTSA complaint #11643148, filed 2025-02

“Engine misfire on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was delivered to Ford of Spartanburg (Ford dealership) for diagnosis. The vehicle is still out of service. Ford's diagnosis, Repair Order 593079, June 26, 2026: WILL NEED TO REPLACE ALL SPARK PLUGS AND WIRES, WILL ALSO NEED TO REPLACED ALL COILS DUE TO MISFIRES ON ALMOST EVERY CYLINDER. The Ford service advisor wrote the same day: The engine also has a misfire that is unrelated to the transmission concern. …”

NHTSA complaint #11763935, filed 2026-09

Related recalls

Related service bulletins

Engine: other model years

YearComplaintsShare of year
202217%
20211150%
2017215%
2014318%
2013215%
2012319%
201115%
2010212%
200838%
200648%
200559%
200437%
200349%
200248%
200136%
200023%
199911%
199812%
199612%

Other parts of the 2021 Ford E-350

Brakes
7 complaints
Steering
7 complaints
Other or unknown
3 complaints
Forward collision avoidance
1 complaints
Fuel system
1 complaints

← All problems reported for the 2021 Ford E-350

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 27, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology