2006 Mercedes-Benz C350 Transmission and drivetrain Problems
- Complaints
- 1about this part
- Share
- 4%of 23 total for the year
- Median mileage
- 43,100miles
- Trend
- Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA recorded 1 complaints about the transmission and drivetrain of the 2006 Mercedes-Benz C350, 4% of the 23 complaints for this model year. Where a mileage was given, the median is 43,100 miles.
Fewer than 15 complaints name this part, so treat the figures as a rough indication only.
Example complaints
Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.
“When driving my '06 C350 with 48 thousand miles, yes 48k on it, the transmission seems to go into a safe mode. It normally occurs when driving at highway speeds and have to slow down gradually, then upon acceleration the transmission just revs up the RPM with no power. I'm afraid me and my two children will be rear-ended due to the loss of power in the transmission. I then try to drive it to the next exit, shut off the engine and restart. This normally resets everything to normal. …”
NHTSA complaint #11142425, filed 2018-10, 43,100 milesRelated service bulletins
- 11035005Jul 14, 2026Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing direction of…
- 11025648Nov 15, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse…
- 11019018May 21, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse…
- 11013298Jan 16, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse…
- 11013332Jan 15, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing…
- 10181124Sep 30, 2020Harsh engagement when changing gear range from P to D or R
- 10166994Feb 25, 2014Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). Heard once when changing from forward to reverse (and vice versa)
- 10029504Feb 1, 2009Mercedes: replace transfer case on affected vehicles optimized transfer cases will reduce vibrations when cornering or when parking. Models 203, 211, 220.
- 10023776Jan 1, 2009Models e320, e500, e55, e350, e550, e63 and s430 4matic, s500 4matic. My 2005-2006 -- replace transfer case. *nj updated 5/13/09. Models c280, c350, c320 and c240. My 2005-2007.
Transmission and drivetrain: other model years
Other parts of the 2006 Mercedes-Benz C350
11 complaintsEngine
5 complaintsAir bags
2 complaintsBrakes
1 complaintsElectrical system
1 complaintsBody and structure
1 complaintsSuspension
1 complaints
← All problems reported for the 2006 Mercedes-Benz C350
About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Nov 1, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.
To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology