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Mercedes-Benz C350Model year report

2006 Mercedes-Benz C350 Problems

Complaints
23filed with NHTSA
Median mileage
71,000miles, 18 complaints with mileage
Recalls
5campaigns on record
Trend
FallingComplaints filed in the last 3 full calendar years are at least 25% lower than in the 3 years before.
NHTSA crash rating
—overall rating starts with 2011 models
EPA fuel economy
21 mpgcombined, 3.5L 6-cyl RWD · 18 city / 27 hwy

Sources: NHTSA records for the 2006 Mercedes-Benz C350 (complaints, recalls, investigations), NHTSA crash tests, EPA fuel economy. Report an error

NHTSA recorded 23 consumer complaints for the 2006 Mercedes-Benz C350. The part named most often is fuel system, with 11 complaints (48% of the total), followed by engine (5) and air bags (2). 18 of the complaints include a mileage, and 28% of those were filed for vehicles with under 50,000 miles; the median is 71,000 miles. Of all complaints, 3 an injury, according to the filers. NHTSA lists 5 recall campaigns and 73 technical service bulletins for this model year. Fuel system complaints overlap with 3 technical service bulletins filed under the same part. Engine complaints overlap with 2 technical service bulletins filed under the same part.

This model year has fewer than 25 complaints on record, so the numbers below can change a lot with a few new reports.

Which parts are reported most

Complaints can name more than one part, so the counts add up to more than the total. Select a part to see its complaints, recalls and bulletins.

Example complaints

Fuel system: “I have a very loud odor of gasoline coming from near my back wheel on the drivers side. The car rides fine and I get good gas mileage but it is not leaking anywhere. I took my backseat out and there was nothing wet. I also replaced the gas cap and it did not help”

NHTSA complaint #10864231, filed 2016-05, 195,000 miles

Engine: “My mercedes e350 reported engine error codes p0016 and p0017. Detailed error code reading. P0016 crankshaft position camshaft position correlation bank 1 sensor a p0017 crankshaft position camshaft position correlation bank 1 sensor b I have 70,000 miles on the car now and have found out that this is a very common problem on the this car. It looks like a manufacturing defect. Please provide me guidance with this matter.”

NHTSA complaint #10481084, filed 2012-10, 69,452 miles

Air bags: “Takata recall no one can tell me when the airbags will be replaced. I am one of the highest risk car owner. My car was manufactured in 2006 and I live in an area that is in one of the highest risk zones..”

NHTSA complaint #11012168, filed 2017-08

Brakes: “The contact owns a 2006 Mercedes-Benz e350. While driving 45 MPH, the brake pedal was depressed, but failed to engage as it traveled to the floorboard. The contact was able to safely coast the vehicle to a gas station. The contact stated that the check engine warning indicator illuminated weeks prior to the failure. The vehicle was towed to Mercedes-Benz of san diego (4750 kearny mesa rd, san diego, ca) where it was diagnosed that the sbc module malfunctioned and needed to be replaced. The manufacturer was not notified of the failure. The failure mileage was approximately 243,000. …”

NHTSA complaint #11088839, filed 2018-04, 243,000 miles

Mileage when problems were reported

28% of the 18 complaints with a mileage were filed for vehicles with under 50,000 miles; the middle half falls between 49,539 and 102,000 miles.

0%0–100%10–2528%25–5028%50–7517%75–10017%100–15011%150+
Share of complaints by mileage when the problem was reported, in thousands of miles (18 complaints with mileage). Red bars: under 50,000 miles. Bucket widths differ. Median: 71,000 miles.

Complaints by year filed

Trend: falling. Complaints filed in the last 3 full calendar years are at least 25% lower than in the 3 years before.

2012201320142015201620172018620212022
Complaints by year the complaint was filed with NHTSA. Red bars: the last 3 full calendar years used for the trend. The current year (2026) is partial.

Crash test ratings

NHTSA's 5-Star Safety Ratings for the 2006 Mercedes-Benz C350. Frontal results are shown driver / passenger; rollover shows the star rating and NHTSA's estimated risk of rolling over in a single-vehicle crash.

VersionOverallFrontalSideSide poleRollover
C-Class · sedan RWD/AWDnot rated4 / 4———

Ratings before the 2011 model year come from an older, less demanding test and are not comparable with ratings for 2011 and later.

Source: NHTSA New Car Assessment Program (5-Star Safety Ratings), nhtsa.gov/ratings.

Fuel economy and running cost

EPA ratings for each 2006 Mercedes-Benz C350 version. Annual fuel cost is the EPA's estimate at its current fuel prices for 15,000 miles a year (55% city driving).

VersionEngineTransmissionCityHwyComb.Fuel / yr
C350 RWD3.5L 6-cyl7-speed automatic182721$3,900
C350 RWD3.5L 6-cyl6-speed manual182621$3,900
C350 4matic 4WD/AWD3.5L 6-cyl5-speed automatic172219$4,350

Source: U.S. EPA and Department of Energy, fueleconomy.gov. Ratings are for comparing vehicles; real-world mileage varies with driving and conditions.

Recalls and investigations

Recall details for the 2006 Mercedes-Benz C350 → · Check a VIN at nhtsa.gov/recalls

Technical service bulletins

TSBs are manufacturer notes to dealers about known repair procedures. They are not recalls and do not by themselves mean a vehicle has a fault. 73 on record; the latest 10 are shown.

See all 73 bulletins →

Other model years of the Mercedes-Benz C350

YearComplaintsMedian miRecallsCrash ★MPGScore (50 = typical)Trend
2015617,2504423—Not enough data
20141360,0004523—Not enough data
20132165,5006523—Falling
20123555,0005—2233 · FewerFalling
20112652,861442029 · FewerFalling
20101899,0604—20—Rising
20096559,1007—2062 · TypicalRising
200814470,0006—20100 · MoreFalling
2007690,8005—21—Not enough data
20062371,0005—21—Falling

All Mercedes-Benz C350 model years · Best and worst years by complaints

Frequently asked questions

How many NHTSA complaints does the 2006 Mercedes-Benz C350 have?

NHTSA recorded 23 consumer complaints for the 2006 Mercedes-Benz C350 as of Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

What part of the 2006 Mercedes-Benz C350 is reported most often?

Fuel system is named most often, in 11 complaints (48% of the total), followed by engine with 5.

Has the 2006 Mercedes-Benz C350 been recalled?

NHTSA lists 5 recall campaigns for this model year. To check a specific vehicle, enter its VIN at nhtsa.gov/recalls.

What gas mileage does the 2006 Mercedes-Benz C350 get?

The EPA rates the 2006 Mercedes-Benz C350 (C350, 3.5L 6-cyl) at 21 mpg combined, 18 city and 27 highway, with an estimated annual fuel cost of $3,900 at 15,000 miles a year. Other engine and drive versions are rated differently.

At what mileage are problems with the 2006 Mercedes-Benz C350 reported?

Among the 18 complaints that include a mileage, the median is 71,000 miles and the middle half falls between 49,539 and 102,000 miles; 28% were filed for vehicles with under 50,000 miles.

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate. Crash ratings are from NHTSA’s New Car Assessment Program. Fuel economy is from the EPA and DOE (fueleconomy.gov).

Complaint counts come from NHTSA’s public complaint database; we count each complaint once. The source records for this vehicle are on nhtsa.gov. Scores and trends are our own summaries of that data, described in the methodology. This page is not legal, safety or repair advice: for a specific vehicle, check its VIN at nhtsa.gov/recalls and ask a qualified mechanic. See an error? Tell us.