2021 Mercedes-Benz E 450 Electrical system Problems
- Complaints
- 3about this part
- Share
- 43%of 7 total for the year
- Median mileage
- 1,772miles
- Trend
- Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA recorded 3 complaints about the electrical system of the 2021 Mercedes-Benz E 450, 43% of the 7 complaints for this model year. Where a mileage was given, the median is 1,772 miles. 3 recall campaigns on record are filed under a similar system.
Fewer than 15 complaints name this part, so treat the figures as a rough indication only.
Example complaints
Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.
“48Volt battery failed after three months and just 3,400 miles. I understand this is a recurring problem with Mercedes. Car had to be towed as the vehicle was totally inoperable due to battery malfunction. It took more than three weeks for Mercedes to provide a replacement battery. From what I have read, there is a strong likelihood that the battery will fail again.”
NHTSA complaint #11427592, filed 2021-08Related recalls
- 24V100000Feb 9, 2024Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The…Covers: Mercedes-Benz E 450 2021–2023, AMG E53 2021–2023, CLS 450 2021–2023 +3 more
- 22V733000Sep 30, 2022Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt…Covers: Mercedes-Benz E 450 2021–2022, CLS 450 2019–2022, AMG E53 2019–2022 +1 more
- 21V354000May 14, 2021Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class…Covers: Mercedes-Benz E 450 2021, A 220 2019–2021, GLE 450 2020–2021 +29 more
Related service bulletins
- 11036511Aug 24, 2026Complaint Tailgate opens unintentionally. Cause Accidental or unnoticed activation of the button to open the tailgate on the vehicle key. EXAMPLE: when stored in trouser pocket…
- 11036190Aug 6, 2026Complaint A popup is seen on the HU with the message "data connection temporarily not available". Potentially affected functionalities in NTG4.5, NTG5 1.Weather 2.Local Search…
- 11035120Jul 17, 2026Complaint Hand detection system – malfunction / vehicles with code 266 Fault message in instrument cluster: "Active Emergency Stop Assist not available" "Active Lane Keeping…
- 11033855Jun 12, 2026Complaint Service code B1 displayed in the customer menu does not match the workshop code displayed in the workshop menu, e.g., 505 or 550A, which includes a service A. Cause The…
- 11033185May 26, 2026Complaint After successful commissioning of the HERMES control unit (N112/9) with XENTRY Diagnosis DVD 03/2026, the message "SOS - service not activated" appears on the…
- 11033016May 26, 2026Complaint The customer requests deactivation of the N112/9 HERMES communication module Note: Deactivation of the HERMES control unit (N112/9) is not supported for gray-market…
- 11031202Apr 7, 2026Complaint When closing the door, the side window may remain slightly open (short stroke position). Automatic window raising function of side window inoperative. NOTE: Window is…
- 11031256Apr 2, 2026Complaint Tailgate opens unintentionally. Cause Accidental or unnoticed activation of the button to open the tailgate on the vehicle key. EXAMPLE: when stored in trouser pocket…
- 11029927Mar 4, 2026Complaint Yellow information message in driver display (instrument cluster): "Switch on motor to charge the 12V battery" Cause The state of charge (SOC) of the 12V battery has…
- 11029087Feb 27, 2026Complaint This LI does Not apply to 223 or 206 which use a different generation of 48V systems. Please follow the relevant guided tests for the 223 and 206. For 223 with fault…
Electrical system: other model years
Other parts of the 2021 Mercedes-Benz E 450
← All problems reported for the 2021 Mercedes-Benz E 450
About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.
To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology