2021 Mercedes-Benz E 450 Engine Problems
- Complaints
- 2about this part
- Share
- 29%of 7 total for the year
- Median mileage
- 2,800miles
- Trend
- Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA recorded 2 complaints about the engine of the 2021 Mercedes-Benz E 450, 29% of the 7 complaints for this model year. Where a mileage was given, the median is 2,800 miles.
Fewer than 15 complaints name this part, so treat the figures as a rough indication only.
Example complaints
Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.
“The 48 volt battery on this mild hybrid vehicle failed and the car was unable to be started on May 3, 2021, with 196 miles on the odometer, a mere 15 days after delivery. It had to be taken by flatbed to the dealer where ultimately the 48 volt battery was replaced. Then again on June 5, 2021, the car was again unable to be started, with a mere 735 miles on the odometer. Again, the car had to be taken by flatbed to the dealer, where ultimately the 48 volt battery was replaced a second time. …”
NHTSA complaint #11441712, filed 2021-11Related service bulletins
- 11038185Sep 26, 2026Complaint Sporadic warning message in instrument cluster "Engine oil pressure, stop switch off vehicle" (or similar) is shown in red on vehicles with low mileage. Cause…
- 11038176Sep 17, 2026Complaint Red coolant warning in instrument cluster. Fault codes U019F00 or U019F87 current/stored in MRG1 control unit. Cause Various causes Remedy Perform guided test for fault…
- 11034064Jun 19, 2026Dear Mercedes-Benz USA Dealers, The part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing PDC. The deadline…
- 11028807Feb 14, 2026Mercedes-Benz AG, the manufacturer of Mercedes-Benz vehicles, has determined that on certain subject vehicles, the engine control unit software does not correspond to current…
- 11026596Dec 6, 2025Complaint <p>ESP®, BAS, PRE-SAFE®, HOLD function, Hill-Start Assist, ESP® trailer stabilization, Adaptive Brake Lights, Lane Keeping Assist, Blind Spot Assist, Adaptive Brake…
- 11015545Mar 4, 2025Complaint Check engine light illuminated Fault code present in MRG3 control unit P22C800 or P22C900 - The valve of the exhaust gas turbocharger is jammed. Cause Check valve in…
- 11012056Dec 19, 2024Complaint Check engine light illuminated Fault code present in MRG3 control unit P22C900 - The valve of the exhaust gas turbocharger is jammed closed. Cause Check valve in charge…
- 11012055Dec 19, 2024Complaint Low engine oil level warning. Engine oil leak under vehicle. Cause Rear crankshaft radial seal rolled during installation Remedy -Check for external oil leak with…
- 11011564Dec 2, 2024Mercedes-Benz AG, the manufacturer of Mercedes-Benz vehicles, has determined that on certain MY 2020-2023 CLS (257 platform), E-Class (213 and 238 platform), GLE (167 platform)…
- 11010744Nov 19, 2024Complaint Engine cooling fan running for an extended time after switching off vehicle. Cause Optimized thermal management in latest PTCU software. Remedy This is a normal…
Engine: other model years
Other parts of the 2021 Mercedes-Benz E 450
← All problems reported for the 2021 Mercedes-Benz E 450
About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.
To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology