2006 Mercedes-Benz R350 Transmission and drivetrain Problems
- Complaints
- 13about this part
- Share
- 13%of 99 total for the year
- Median mileage
- 72,000miles
- Trend
- Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA recorded 13 complaints about the transmission and drivetrain of the 2006 Mercedes-Benz R350, 13% of the 99 complaints for this model year. Where a mileage was given, the median is 72,000 miles. 1 of these say a crash was involved, according to the filers.
Fewer than 15 complaints name this part, so treat the figures as a rough indication only.
Example complaints
Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.
“I have a 2006 mercedes R350 that we bought used in 2009. The car now has 51,560 miles and the front differential is out and needs replaced at a cost of 3500.00. I have read of several complaints for the same problem with the same mileage on the car. Mercedes is aware of the problem but refuses to issue a recall. I am fighting with them now to just get them to cover half the cost. Even though it is out of warranty, the problem started before the warranty was out and I called the dealer. …”
NHTSA complaint #10395375, filed 2011-04, 51,560 miles“Check engine light came on, took the car to my mechanic that works on foreign cars, he informed me that my drive cam shaft is retarded basically stating that my sprockets that hold the timing belt are worn down, I am also loosing compression. I took it to the mercedes dealership and they told me they will goodwill the repair if that is really what is wrong with it. They however proceeded to tell me that your car has almost 100,000 miles on it, so it may just be the timing belt is worn down.(they will try anything to get out of the repair). …”
NHTSA complaint #10450538, filed 2012-03, 92,261 miles“My wife drove our mercedes benz R350 to a friends house to drop off the kids. Upon stopping on the driveway my wife shut the car off (key in off position) got out and went to the passenger side to help my daughter out of the third row. At that same time my son exited the vehicle and was standing outside the car. As my wife began to move the seat for my daughter the car rolled due to not being in park, rolled past my son and went through the friends garage door. All cars I know of that are automatics require the vehicle be in park prior to the key going to the off position. …”
NHTSA complaint #10157229, filed 2006-05, 1,900 miles“Car goes into limp mode cant drive faster than 20mph on freeway very dangerous. Have to pull over turn off engine and restart car to reset. Car just randomly shut off all electronics died on street. Towed car to dealership says needs new valve body of transmission. Researched online very common problem. Defect in manufacturing and parts.”
NHTSA complaint #10949628, filed 2017-02, 128,000 miles“The vehicle indicated check engine light and the error code shows p0016 which is shaft balance issue. The dealer and manufacturer would not attend to it despite the fact that it a known error from factory. The issue would reoccur because of poor material and could cause the car to stall while in travel.”
NHTSA complaint #10411070, filed 2011-06, 68,080 milesRelated service bulletins
- 11035005Jul 14, 2026Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing direction of…
- 11025648Nov 15, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse…
- 11019018May 21, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse…
- 11013298Jan 16, 2025Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse…
- 10135653Oct 27, 2014Procedure in case of slight oil traces on TRANSMISSION 722.9
- 10135649Oct 23, 2014Procedure in case of slight oil traces on TRANSMISSION 722.9
- 10044200Apr 2, 2012Xentry: mercedes benz: grunting/creaking sound from the area of the front axle when braking, driving over surface undulations, negotiating tight corners, or while maneuvering…
- 10021242Sep 1, 2006Coating formation on gear selector actuator motor (ism motor).
Transmission and drivetrain: other model years
Other parts of the 2006 Mercedes-Benz R350
26 complaintsEngine
17 complaintsEngine cooling
16 complaintsElectrical system
14 complaintsSeats
9 complaintsExterior lighting
7 complaintsSteering
5 complaintsFuel system
4 complaintsOther or unknown
4 complaintsAir bags
3 complaintsBrakes
3 complaintsBody and structure
3 complaints
← All problems reported for the 2006 Mercedes-Benz R350
About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.
To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology