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Mercedes-Benz S 500 4MATICModel year report

2022 Mercedes-Benz S 500 4MATIC Problems

Complaints
21filed with NHTSA
Median mileage
4,800miles, 5 complaints with mileage
Recalls
91 do-not-drive
Trend
RisingComplaints filed in the last 3 full calendar years are at least 25% higher than in the 3 years before.
NHTSA crash rating
—no overall rating published
EPA fuel economy
24 mpgcombined, 3.0L 6-cyl · hybrid AWD · 21 city / 30 hwy

Sources: NHTSA records for the 2022 Mercedes-Benz S 500 4MATIC (complaints, recalls, investigations), EPA fuel economy. Report an error

NHTSA recorded 21 consumer complaints for the 2022 Mercedes-Benz S 500 4MATIC. The part named most often is forward collision avoidance, with 8 complaints (38% of the total), followed by electrical system (6) and fuel system (3). 5 of the complaints include a mileage, and 100% of those were filed for vehicles with under 50,000 miles; the median is 4,800 miles. Of all complaints, 2 an injury, according to the filers. NHTSA lists 9 recall campaigns (1 marked do-not-drive) and 319 technical service bulletins for this model year. Forward collision avoidance complaints overlap with 5 technical service bulletins filed under the same part. Electrical system complaints overlap with 1 recall campaign and 168 technical service bulletins filed under the same part.

This model year has fewer than 25 complaints on record, so the numbers below can change a lot with a few new reports.

Which parts are reported most

Complaints can name more than one part, so the counts add up to more than the total. Select a part to see its complaints, recalls and bulletins.

Also reported: Engine (1), Exterior lighting (1), Transmission and drivetrain (1), Visibility (wipers, defrost, mirrors) (1), Wheels (1).

Example complaints

Forward collision avoidance: “Here we go again, while driving on a side road with a 20 mph school speed limit, the cruise control wants to SPEED UP to 60 mph!! WHAT IS IT GOING TO TAKE TO REMEDY THIS BEFORE I’M INVOLVED IN A SERIOUS ACCIDENT!!”

NHTSA complaint #11650963, filed 2025-03

Electrical system: “The car slams on the brakes for no reason. phantom braking. i have been tailgated because cars behind me - particularly on tye highway - think i’ve brake checked them (but it was the care slamming on the brakes). the door handles don’t open/deploy reliably. sometimes they work, sometimes they don’t. the touch screens are incredibly dangerous - especially when the system freezes or doesn’t work properly - which is often. there are almost no physical buttons. the system software & touchscreens are VERY glitchy and often doesn’t function properly. …”

NHTSA complaint #11614618, filed 2024-09

Fuel system: “The contact owns a 2022 Mercedes-Benz S500. The contact stated that while driving at 50 MPH, the vehicle inadvertently lost motive power, but the contact was able to pull to the shoulder of the roadway. After restarting the vehicle, the vehicle seemed to return to normal functionality. The check engine warning light was illuminated. The vehicle was taken to the dealer, who was unable to determine the cause of the failure. The vehicle was repaired, but the failure reoccurred. …”

NHTSA complaint #11541446, filed 2023-08, 34,000 miles

Body and structure: “We're on our fifth windshield, and I'm concerned that there is some sort of structural issue. We've lived in the same area for more than 10 years and have never had this problem with any of our other cars, SUVs, or trucks. Sometimes, it sounds like a piece of sand has hit the windshield, and BOOM...another cracked windshield, but it always cracks on the driver's side. This isn't normal. Also, settings don't save to our profiles, and the backup warning signal doesn't work dependably. We've had these things looked at several times by the dealership. They have no answers.”

NHTSA complaint #11592292, filed 2024-06

Mileage when problems were reported

100% of the 5 complaints with a mileage were filed for vehicles with under 50,000 miles; the middle half falls between 2,000 and 12,000 miles.

60%0–1020%10–2520%25–500%50–750%75–1000%100–1500%150+
Share of complaints by mileage when the problem was reported, in thousands of miles (5 complaints with mileage). Red bars: under 50,000 miles. Bucket widths differ. Median: 4,800 miles.

Complaints by year filed

Trend: rising. Complaints filed in the last 3 full calendar years are at least 25% higher than in the 3 years before.

202220232024620252026
Complaints by year the complaint was filed with NHTSA. Red bars: the last 3 full calendar years used for the trend. The current year (2026) is partial.

Fuel economy and running cost

EPA ratings for each 2022 Mercedes-Benz S 500 4MATIC version. Annual fuel cost is the EPA's estimate at its current fuel prices for 15,000 miles a year (55% city driving).

VersionEngineTransmissionCityHwyComb.Fuel / yr
S500 4matic AWD3.0L 6-cyl · hybrid9-speed automatic213024$3,400

Source: U.S. EPA and Department of Energy, fueleconomy.gov. Ratings are for comparing vehicles; real-world mileage varies with driving and conditions.

Recalls and investigations

See all 9 recalls for the 2022 Mercedes-Benz S 500 4MATIC → · Check a VIN at nhtsa.gov/recalls

Technical service bulletins

TSBs are manufacturer notes to dealers about known repair procedures. They are not recalls and do not by themselves mean a vehicle has a fault. 319 on record; the latest 10 are shown.

See all 319 bulletins →

Other model years of the Mercedes-Benz S 500 4MATIC

YearComplaintsMedian miRecallsCrash ★MPGScore (50 = typical)Trend
2022214,8009—24—Rising

All Mercedes-Benz S 500 4MATIC model years

Frequently asked questions

How many NHTSA complaints does the 2022 Mercedes-Benz S 500 4MATIC have?

NHTSA recorded 21 consumer complaints for the 2022 Mercedes-Benz S 500 4MATIC as of Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

What part of the 2022 Mercedes-Benz S 500 4MATIC is reported most often?

Forward collision avoidance is named most often, in 8 complaints (38% of the total), followed by electrical system with 6.

Has the 2022 Mercedes-Benz S 500 4MATIC been recalled?

NHTSA lists 9 recall campaigns for this model year, 1 of them with a do-not-drive advisory. To check a specific vehicle, enter its VIN at nhtsa.gov/recalls.

What gas mileage does the 2022 Mercedes-Benz S 500 4MATIC get?

The EPA rates the 2022 Mercedes-Benz S 500 4MATIC (S500 4matic, 3.0L 6-cyl · hybrid) at 24 mpg combined, 21 city and 30 highway, with an estimated annual fuel cost of $3,400 at 15,000 miles a year. Other engine and drive versions are rated differently.

At what mileage are problems with the 2022 Mercedes-Benz S 500 4MATIC reported?

Among the 5 complaints that include a mileage, the median is 4,800 miles and the middle half falls between 2,000 and 12,000 miles; 100% were filed for vehicles with under 50,000 miles.

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate. Fuel economy is from the EPA and DOE (fueleconomy.gov).

Complaint counts come from NHTSA’s public complaint database; we count each complaint once. The source records for this vehicle are on nhtsa.gov. Scores and trends are our own summaries of that data, described in the methodology. This page is not legal, safety or repair advice: for a specific vehicle, check its VIN at nhtsa.gov/recalls and ask a qualified mechanic. See an error? Tell us.