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Transmission and drivetrainPart report

2022 Mercedes-Benz S 580 4MATIC Transmission and drivetrain Problems

Complaints
4about this part
Share
16%of 25 total for the year
Median mileage
9,150miles
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 4 complaints about the transmission and drivetrain of the 2022 Mercedes-Benz S 580 4MATIC, 16% of the 25 complaints for this model year. Where a mileage was given, the median is 9,150 miles.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“While driving on the freeway at approximately 40 mph on May 10, the yellow check engine light came on. I was approximately 200 miles into the current tank of gas, I stopped and checked to make sure the gas cap was properly secured. There were no obvious drivability issues. I immediately dropped the car off at Mercedes of Ontario, California, and they were able to confirm the problem, but could not clear the code, or determine the root cause of failure. Ontario Mercedes has now had my car for 6, days and that they are waiting for a M/B factory technician to tell them what to do.”

NHTSA complaint #11522006, filed 2023-05

“The contact owns a 2022 Mercedes-Benz S 580. The contact stated that while driving at an undisclosed speed, the messages Active Brake Assist Functions Currently Limited - See Owner's Manual , Risk of Vehicle Rolling Away - N Activated Manually No Automatic Change To P , Service Required Do Not Change Transmission Position , and Active Parking Assist And Parktronic Inoperative - See Owner's Manual were displayed, and an unknown warning light was illuminated. Additionally, the vehicle had experienced phantom braking and the transmission failed to shift into park(P) as needed. …”

NHTSA complaint #11763035, filed 2026-09, 18,000 miles

“The contact owns a 2022 Mercedes-Benz S580. The contact stated that while driving at an undisclosed speed, the vehicle vibrated violently. The low tire air pressure warning light was illuminated. The vehicle was taken to the dealer, who diagnosed a failure with the front driver’s side tire. The contact was informed that bubbles had developed on the tire side wall, requiring a replacement. The vehicle was repaired, but the failure reoccurred. The vehicle was taken back to the dealer, who diagnosed an additional failure with the front driver’s side wheel requiring a replacement. …”

NHTSA complaint #11546039, filed 2023-09, 300 miles

“Vehicle: 2022 Mercedes-Benz S580 The vehicle is experiencing a severe and violent drivetrain jolt or push during gear transitions, specifically when shifting from 5th to 6th gear at cruising speeds. On multiple occasions, the jolt was so forceful that passengers believed the vehicle had been rear-ended by another car. This behavior is unpredictable and creates a significant safety hazard, as it causes a sudden change in vehicle momentum while driving in traffic. The issue has been reported to the authorized dealer (Fields Mercedes Lakeland) multiple times. …”

NHTSA complaint #11732269, filed 2026-04

Related service bulletins

Transmission and drivetrain: other model years

YearComplaintsShare of year
2022416%

Other parts of the 2022 Mercedes-Benz S 580 4MATIC

Forward collision avoidance
8 complaintsBrakes
7 complaintsEngine
6 complaintsElectrical system
5 complaintsSuspension
3 complaintsTires
3 complaintsEngine cooling
2 complaintsFuel system
2 complaintsWheels
2 complaintsBack-over prevention (rear camera)
1 complaintsOther or unknown
1 complaintsSeat belts
1 complaints

← All problems reported for the 2022 Mercedes-Benz S 580 4MATIC

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Nov 1, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology