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EnginePart report

2021 GMC Sierra 2500 Engine Problems

Complaints
8about this part
Share
15%of 52 total for the year
Median mileage
66,000miles
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 8 complaints about the engine of the 2021 GMC Sierra 2500, 15% of the 52 complaints for this model year. Where a mileage was given, the median is 66,000 miles.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“I am reporting repeated failures involving both the transmission and diesel emissions (DEF) system on my 2021 GMC Sierra 2500HD Denali equipped with the 6.6L Duramax diesel engine and Allison 10-speed automatic transmission. While under warranty, the truck required replacement of the aftertreatment fuel injector and later the Reductant Control Module due to DEF/emissions system failures. General Motors also completed recall-related transmission software updates on the vehicle. …”

NHTSA complaint #11746749, filed 2026-06

“The contact owns a 2021 GMC Sierra 2500. The contact stated that while driving at 55 MPH, the vehicle stalled unexpectedly. There were no warning lights illuminated. The vehicle was taken to the local dealer, where it was diagnosed, and determined that the engine needed to be replaced. The engine was replaced; however, the failure recurred. While at a stop and attempting to drive around a curve, the vehicle stalled. No warning lights were illuminated. The vehicle was taken to the local dealer, where it was diagnosed with engine failure. The vehicle was not repaired. …”

NHTSA complaint #11728457, filed 2026-04, 77,000 miles

“The contact owns a 2021 GMC Sierra 2500. The contact stated that the vehicle was equipped with an engine block heater that he plugged into the vehicle when the weather was below 32 degrees to start the vehicle. The contact stated that he noticed that the engine block heater was causing the GFCI outlet in his residence, to experience an electrical short circuit. The dealer was notified of the failure and informed the contact that it was a known failure. An appointment was scheduled for diagnostic testing. The vehicle was not diagnosed or repaired. …”

NHTSA complaint #11574476, filed 2024-02, 55,000 miles

“The contact owns a 2021 GMC Sierra 2500. The contact stated while driving 40-55 MPH, the vehicle started losing motive power. The contact stated while pulling into a nearby independent mechanic shop, the vehicle started jerking significantly and stalled midway. The check engine warning light was illuminated. The mechanic diagnosed the vehicle with transmission failure. The vehicle was towed to the residence. The local dealer and several unknown dealers were notified of the failure and informed the contact that the transmission assembly was not available and could not be ordered. …”

NHTSA complaint #11631610, filed 2024-12, 134,000 miles

Related service bulletins

Engine: other model years

YearComplaintsShare of year
202618%
2025414%
20241211%
202339%
202249%
2021815%
20201013%
2019619%
2018823%
2017616%
2016915%
201578%
2014310%
201312%
2012310%
201158%
2010110%
200926%
200846%
200711%
200554%
200496%
200364%
200221%
200186%

Other parts of the 2021 GMC Sierra 2500

Transmission and drivetrain
13 complaints
Exterior lighting
9 complaints
Brakes
7 complaints
Electrical system
6 complaints
Body and structure
5 complaints
Latches, locks and linkages
4 complaints
Forward collision avoidance
3 complaints
Other or unknown
3 complaints
Air bags
2 complaints
Fuel system
2 complaints
Back-over prevention (rear camera)
1 complaints
Lane departure
1 complaints

← All problems reported for the 2021 GMC Sierra 2500

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 27, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology