Skip to content
Fuel systemPart report

2021 GMC Sierra 2500 Fuel system Problems

Complaints
2about this part
Share
4%of 52 total for the year
Median mileage
—not reported
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 2 complaints about the fuel system of the 2021 GMC Sierra 2500, 4% of the 52 complaints for this model year.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“After finishing a long drive south, I shut the engine off and a yellow engine code popped on. I connected my computer to it and revealed a P129F code (fuel pump control module). I have noticed that other GMC models have been included in a recall concerning this problem. The 2021 GMC 2500 Denali should be also since it is the same problem. This needs to be covered by the manufacturer since it is a constant problem.”

NHTSA complaint #11753689, filed 2026-07

“I am reporting repeated failures involving both the transmission and diesel emissions (DEF) system on my 2021 GMC Sierra 2500HD Denali equipped with the 6.6L Duramax diesel engine and Allison 10-speed automatic transmission. While under warranty, the truck required replacement of the aftertreatment fuel injector and later the Reductant Control Module due to DEF/emissions system failures. General Motors also completed recall-related transmission software updates on the vehicle. …”

NHTSA complaint #11746749, filed 2026-06

Related service bulletins

Fuel system: other model years

YearComplaintsShare of year
202618%
202514%
202498%
202249%
202124%
202023%
2019619%
2018617%
201738%
20161220%
20151213%
2014310%
2013920%
2012516%
201135%
200926%
200846%
200734%
200623%
200533%
200486%
2003159%
2002129%
2001129%
200024%
199926%
1998213%
199717%

Other parts of the 2021 GMC Sierra 2500

Transmission and drivetrain
13 complaints
Exterior lighting
9 complaints
Engine
8 complaints
Brakes
7 complaints
Electrical system
6 complaints
Body and structure
5 complaints
Latches, locks and linkages
4 complaints
Forward collision avoidance
3 complaints
Other or unknown
3 complaints
Air bags
2 complaints
Back-over prevention (rear camera)
1 complaints
Lane departure
1 complaints

← All problems reported for the 2021 GMC Sierra 2500

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 30, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology