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Mercedes-Benz E 450Model year report

2022 Mercedes-Benz E 450 Problems

Complaints
11filed with NHTSA
Median mileage
400miles, 1 complaints with mileage
Recalls
5campaigns on record
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA crash rating
5 / 5stars overall, 2 rated versions
EPA fuel economy
25 mpgcombined, 3.0L 6-cyl · hybrid 4WD · 23 city / 30 hwy

Sources: NHTSA records for the 2022 Mercedes-Benz E 450 (complaints, recalls, investigations), NHTSA crash tests, EPA fuel economy. Report an error

NHTSA recorded 11 consumer complaints for the 2022 Mercedes-Benz E 450. The part named most often is electrical system, with 4 complaints (36% of the total), followed by fuel system (3) and brakes (2). 1 of the complaints include a mileage, and 100% of those were filed for vehicles with under 50,000 miles; the median is 400 miles. NHTSA lists 5 recall campaigns and 207 technical service bulletins for this model year. Electrical system complaints overlap with 2 recall campaigns and 88 technical service bulletins filed under the same part. Fuel system complaints overlap with 2 recall campaigns covering the fuel pump and 7 technical service bulletins filed under the same part.

This model year has fewer than 25 complaints on record, so the numbers below can change a lot with a few new reports.

Which parts are reported most

Complaints can name more than one part, so the counts add up to more than the total. Select a part to see its complaints, recalls and bulletins.

Example complaints

Electrical system: “Twice within a year a 48 voltage battery malfunction warning appeared on my dashboard. Then a red warning light appears and I had about 30 seconds to find a safe place to pull over as loss of power causes deceleration of the vehicle . The cause, according to the diagnostic test performed by 2 different Mercedes dealerships, is that a software update is needed. A know of no situation where the machine crashes first then you're told to update its software. …”

NHTSA complaint #11629635, filed 2024-12

Fuel system: “there is a recall on my vehicle for over 4 months now. i keep going/contacting the local dealers about the issue and they keep telling me to come back in a month and every time they tell me there is no remedy yet and they dont know when exactly they will be able to fix it. and according to NHTSA this could increase the risk of crash or injury. please help me either get this fixed or make sure its safe for me to drive. thank you”

NHTSA complaint #11554671, filed 2023-11

Brakes: “I was driving the car on a road I drive daily with my son in a child seat in the back row. The car inexplicably slammed on the brakes at full force, stopping in time to avoid driving over the shadow of a tree. Approximately thirty minutes later, there was a loud popping / explosion sound from inside the engine compartment, the car lost all power, coasted along for approximately 100 feet, and then restarted while coasting. This is the second time in under a year that the car has experienced a major electrical system malfunction.”

NHTSA complaint #11487625, filed 2022-10

Wheels: “When turning the steering to maximum wheel camber, the wheel rims roll over the sidewall of the OEM low-profile Pirelli tires, damaging the tires and causing bubbling in the sidewall. This happens at a negligible speed, such as exiting a parking space. This vehicle is 3+ years old with 15k miles. Low-profile tires appear to be incompatible with the steering design.”

NHTSA complaint #11724597, filed 2026-03

Mileage when problems were reported

100% of the 1 complaints with a mileage were filed for vehicles with under 50,000 miles; the middle half falls between 400 and 400 miles.

100%0–100%10–250%25–500%50–750%75–1000%100–1500%150+
Share of complaints by mileage when the problem was reported, in thousands of miles (1 complaints with mileage). Red bars: under 50,000 miles. Bucket widths differ. Median: 400 miles.

Complaints by year filed

Fewer than 15 complaints, too few for a reliable trend.

202242023420242026
Complaints by year the complaint was filed with NHTSA. Red bars: the last 3 full calendar years used for the trend. The current year (2026) is partial.

Crash test ratings

NHTSA's 5-Star Safety Ratings for the 2022 Mercedes-Benz E 450. Frontal results are shown driver / passenger; rollover shows the star rating and NHTSA's estimated risk of rolling over in a single-vehicle crash.

VersionOverallFrontalSideSide poleRollover
E-Class · sedan 4WD★★★★★4 / 5555 · 9.7% risk
E-Class · sedan RWD★★★★★4 / 5555 · 9.7% risk

Driver aids listed by NHTSA for the 2022 model year: forward collision warning standard, lane departure warning not available, automatic emergency braking not available.

Neighbouring years: 2021: same overall rating; 2023: same overall rating. A redesign between years can change both the car and the test.

Source: NHTSA New Car Assessment Program (5-Star Safety Ratings), nhtsa.gov/ratings.

Fuel economy and running cost

EPA ratings for each 2022 Mercedes-Benz E 450 version. Annual fuel cost is the EPA's estimate at its current fuel prices for 15,000 miles a year (55% city driving).

VersionEngineTransmissionCityHwyComb.Fuel / yr
E450 4matic 4WD3.0L 6-cyl · hybrid9-speed automatic233025$3,300
E450 4matic All-Terrain (wagon) 4WD3.0L 6-cyl · hybrid9-speed automatic212824$3,400
E450 4matic Convertible 4WD3.0L 6-cyl · hybrid9-speed automatic222924$3,400
E450 4matic Coupe 4WD3.0L 6-cyl · hybrid9-speed automatic213024$3,400
E450 Convertible RWD3.0L 6-cyl · hybrid9-speed automatic222925$3,300
E450 Coupe RWD3.0L 6-cyl · hybrid9-speed automatic222925$3,300

Source: U.S. EPA and Department of Energy, fueleconomy.gov. Ratings are for comparing vehicles; real-world mileage varies with driving and conditions.

Recalls and investigations

Recall details for the 2022 Mercedes-Benz E 450 → · Check a VIN at nhtsa.gov/recalls

Technical service bulletins

TSBs are manufacturer notes to dealers about known repair procedures. They are not recalls and do not by themselves mean a vehicle has a fault. 207 on record; the latest 10 are shown.

See all 207 bulletins →

Other model years of the Mercedes-Benz E 450

YearComplaintsMedian miRecallsCrash ★MPGScore (50 = typical)Trend
2023176004525—Too new
2022114005525—Not enough data
202171,00014525—Not enough data
2020941,0007523—Not enough data
2019177,20012523—Rising

All Mercedes-Benz E 450 model years

Frequently asked questions

How many NHTSA complaints does the 2022 Mercedes-Benz E 450 have?

NHTSA recorded 11 consumer complaints for the 2022 Mercedes-Benz E 450 as of Nov 1, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

What part of the 2022 Mercedes-Benz E 450 is reported most often?

Electrical system is named most often, in 4 complaints (36% of the total), followed by fuel system with 3.

Has the 2022 Mercedes-Benz E 450 been recalled?

NHTSA lists 5 recall campaigns for this model year. To check a specific vehicle, enter its VIN at nhtsa.gov/recalls.

How did the 2022 Mercedes-Benz E 450 do in NHTSA crash tests?

NHTSA's 5-Star Safety Ratings give the 2022 Mercedes-Benz E 450 5 out of 5 stars overall, across 2 rated versions (body style and drive). Ratings from different model years are only comparable when the vehicle was not redesigned in between.

What gas mileage does the 2022 Mercedes-Benz E 450 get?

The EPA rates the 2022 Mercedes-Benz E 450 (E450 4matic, 3.0L 6-cyl · hybrid) at 25 mpg combined, 23 city and 30 highway, with an estimated annual fuel cost of $3,300 at 15,000 miles a year. Other engine and drive versions are rated differently.

At what mileage are problems with the 2022 Mercedes-Benz E 450 reported?

Among the 1 complaints that include a mileage, the median is 400 miles and the middle half falls between 400 and 400 miles; 100% were filed for vehicles with under 50,000 miles.

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Nov 1, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate. Crash ratings are from NHTSA’s New Car Assessment Program. Fuel economy is from the EPA and DOE (fueleconomy.gov).

Complaint counts come from NHTSA’s public complaint database; we count each complaint once. The source records for this vehicle are on nhtsa.gov. Scores and trends are our own summaries of that data, described in the methodology. This page is not legal, safety or repair advice: for a specific vehicle, check its VIN at nhtsa.gov/recalls and ask a qualified mechanic. See an error? Tell us.