2006 Mercedes-Benz E350 Engine Problems
- Complaints
- 50about this part
- Share
- 13%of 400 total for the year
- Median mileage
- 111,000miles
- Trend
- FallingComplaints filed in the last 3 full calendar years are at least 25% lower than in the 3 years before.
NHTSA recorded 50 complaints about the engine of the 2006 Mercedes-Benz E350, 13% of the 400 complaints for this model year. Where a mileage was given, the median is 111,000 miles. 4 of these say a crash was involved and 2 a fire, according to the filers.
Example complaints
Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.
“I am reporting a very serious, disturbing, shocking and tragic accident on 9/12/2015 on randall road in elgin, il USA at 2:35 pm just after big timber road signal.my southbound 2006 mercedes benz E350 car was hit by the high speed out of control northbound 2014 toyota corolla, which had crossed/swerved the center line and resulted in a head on collision/crash.....updated 10-27-15”
NHTSA complaint #10779783, filed 2015-10, 117,000 miles“My 2006 mercedes benz 350 e series had gotten in a accident due to the car stalling out. I have a code reader and will provide the necessary pictures I took the day prior of the accident.”
NHTSA complaint #11032152, filed 2017-10, 143,000 miles“This vehicle is a threat to my health with all the problems I'm having with it. I have to press extra had to stop . Had brakes checked and there was no problem. There is a bad gasoline leak and loud smell of gas when I fill up. Looked under rear seat and saw gas on gas tank. Dried gas up and the big puddle returned. Can I drive this car? I need someone to tell me what to do. The last and most worrisome thing to me is that there are 2 DTC codes coming up causing the check engine light to come on. Had mechanic to clear then but they come right back when car is started. …”
NHTSA complaint #11310454, filed 2020-02, 154,000 miles“The engine of my car stalled suddenly, braking power was reduced dramatically. I was about to get into a serious crash but likely this happened in a local street at a traffic light when everyone was ready to slow down and stop. My dealer told me the engine stalled due to a broken vacuum intake manifold linkage which controls air in and out in the system. The only way to fix is to replace the entire manifold ($2100) and mercedes benz does not offer an extended warranty on this component. …”
NHTSA complaint #10777922, filed 2015-09, 107,000 miles“There is a serious safety issue with 2006 Mercedes-Benz e class (mbec) because of a manufacturer's and/or design defect which causes this vehicle to not go into proper gear and/or stall suddenly putting the public at risk. I barely escaped being smashed into by oncoming traffic while making a routine left hand turn into a gas station because my mbec was stuck in gear and did not accelerate as it was manufactured and designed to do but rather sputtered at less than 5 miles per hour (MPH). …”
NHTSA complaint #10695497, filed 2015-03, 103,586 milesRelated service bulletins
- 11017039Apr 1, 2025Complaint Vehicle with atypical reduced heat output. Cause Silicate granulate may have escaped from a damaged bag in the expansion reservoir (not visible), reducing the coolant…
- 10158329Oct 9, 2017Oil in engine wiring harness
- 11031629Oct 30, 2015To enhance the satisfaction of our customers, avoid further costs of litigation and return focus to its core businesses, Mercedes-Benz USA, LLC (MBUSA) entered into a settlement…
- 10135598Mar 25, 2015Engine diagnosis warning lamp lights up in instrument cluster, fault code U145400: "Implausible data were received from the ethanol sensor"
- 10051540Oct 26, 2012Xentry: m271.8 evo engine has poor accelerator response- lack of power under full load and high rpm. Engine diagnosis warning lamp (cel) lights up, vehicle is in limp-home mode…
Engine: other model years
| Year | Complaints | Share of year |
|---|---|---|
| 2021 | 4 | 31% |
| 2020 | 3 | 38% |
| 2017 | 2 | 29% |
| 2016 | 5 | 10% |
| 2015 | 2 | 6% |
| 2014 | 20 | 7% |
| 2013 | 15 | 9% |
| 2012 | 20 | 9% |
| 2011 | 13 | 6% |
| 2010 | 15 | 8% |
| 2009 | 5 | 8% |
| 2008 | 13 | 8% |
| 2007 | 28 | 8% |
| 2006 | 50 | 13% |
Other parts of the 2006 Mercedes-Benz E350
219 complaintsBrakes
54 complaintsTransmission and drivetrain
37 complaintsEngine cooling
22 complaintsElectrical system
19 complaintsAir bags
13 complaintsOther or unknown
11 complaintsVisibility (wipers, defrost, mirrors)
8 complaintsVehicle speed control
7 complaintsSteering
6 complaintsElectronic stability control
5 complaintsExterior lighting
5 complaints
← All problems reported for the 2006 Mercedes-Benz E350
About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.
To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology