2021 Mercedes-Benz E350 Engine Problems
- Complaints
- 4about this part
- Share
- 31%of 13 total for the year
- Median mileage
- —not reported
- Trend
- Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA recorded 4 complaints about the engine of the 2021 Mercedes-Benz E350, 31% of the 13 complaints for this model year. 1 a fire, according to the filers.
Fewer than 15 complaints name this part, so treat the figures as a rough indication only.
Example complaints
Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.
“Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.”
NHTSA complaint #11707258, filed 2025-12“FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.”
NHTSA complaint #11629406, filed 2024-12“The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. …”
NHTSA complaint #11571057, filed 2024-02Related service bulletins
- 11038176Sep 17, 2026Complaint Red coolant warning in instrument cluster. Fault codes U019F00 or U019F87 current/stored in MRG1 control unit. Cause Various causes Remedy Perform guided test for fault…
- 11030302Mar 27, 2026Complaint -Check engine light illuminated. -Engine runs rough. -Poor shifting or jerking when accelerating. -Fault codes stored related to mixture formation, injector quantity…
- 11028807Feb 14, 2026Mercedes-Benz AG, the manufacturer of Mercedes-Benz vehicles, has determined that on certain subject vehicles, the engine control unit software does not correspond to current…
- 11028267Feb 2, 2026Complaint -Check engine light illuminated. -Engine runs rough. -Poor shifting or jerking when accelerating. -Fault codes stored related to mixture formation, injector quantity…
- 11028003Jan 23, 2026Dear Mercedes-Benz Owner: In our continuing efforts to ensure the proper performance of Mercedes-Benz products and to enhance the satisfaction of our customers, Mercedes-Benz USA…
- 11027580Jan 10, 2026In our continuing efforts to ensure the proper performance of Mercedes-Benz products and to enhance the satisfaction of our customers, Mercedes-Benz USA, LLC is extending the…
- 11026596Dec 6, 2025Complaint <p>ESP®, BAS, PRE-SAFE®, HOLD function, Hill-Start Assist, ESP® trailer stabilization, Adaptive Brake Lights, Lane Keeping Assist, Blind Spot Assist, Adaptive Brake…
- 11018530May 15, 2025Complaint Check engine light illuminated Fault code stored in N3/10 control unit- P052E71 – Positive Crankcase Ventilation Regulator Valve Performance: The valve for crankcase…
- 11011564Dec 2, 2024Mercedes-Benz AG, the manufacturer of Mercedes-Benz vehicles, has determined that on certain MY 2020-2023 CLS (257 platform), E-Class (213 and 238 platform), GLE (167 platform)…
- 11008712Oct 4, 2024Complaint Check engine light on. One of the below fault codes is current in the engine control module (N3/10). P04DB29, P04DB31, P04DB79 Cause Open circuit or high resistance to…
Engine: other model years
| Year | Complaints | Share of year |
|---|---|---|
| 2021 | 4 | 31% |
| 2020 | 3 | 38% |
| 2017 | 2 | 29% |
| 2016 | 5 | 10% |
| 2015 | 2 | 6% |
| 2014 | 20 | 7% |
| 2013 | 15 | 9% |
| 2012 | 20 | 9% |
| 2011 | 13 | 6% |
| 2010 | 15 | 8% |
| 2009 | 5 | 8% |
| 2008 | 13 | 8% |
| 2007 | 28 | 8% |
| 2006 | 50 | 13% |
Other parts of the 2021 Mercedes-Benz E350
4 complaintsBack-over prevention (rear camera)
3 complaintsFuel system
3 complaintsTransmission and drivetrain
3 complaintsBrakes
1 complaints
← All problems reported for the 2021 Mercedes-Benz E350
About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 29, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.
To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology