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Fuel systemPart report

2021 Mercedes-Benz E350 Fuel system Problems

Complaints
3about this part
Share
23%of 13 total for the year
Median mileage
53,200miles
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 3 complaints about the fuel system of the 2021 Mercedes-Benz E350, 23% of the 13 complaints for this model year. Where a mileage was given, the median is 53,200 miles. 1 recall campaign on record is filed under a similar system.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced. The vehicle was not repaired. The local dealer and manufacturer were notified of the failure and informed the contact that the VIN was not included in NHTSA Campaign Number: 23V445000 (Fuel System, Gasoline). The contact stated that the vehicle had experienced that failure listed in the recall. …”

NHTSA complaint #11567020, filed 2024-01, 53,200 miles

“The engine is misfiring and not powering correctly during driving. Car is failing to take off and today almost caused an accident due to the car would not pull off from the traffic light with oncoming traffic due to loss of power. …”

NHTSA complaint #11571057, filed 2024-02

Related recalls

Related service bulletins

Fuel system: other model years

YearComplaintsShare of year
2022111%
2021323%
2020225%
2017229%
201648%
201526%
20143613%
2013117%
20123516%
20113214%
20102011%
20093352%
20088650%
200725372%
200621955%
2005533%
2004990%
2003229%

Other parts of the 2021 Mercedes-Benz E350

Electrical system
4 complaints
Engine
4 complaints
Back-over prevention (rear camera)
3 complaints
Transmission and drivetrain
3 complaints
Brakes
1 complaints

← All problems reported for the 2021 Mercedes-Benz E350

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology