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Mercedes-Benz E350Model year report

2021 Mercedes-Benz E350 Problems

Complaints
13filed with NHTSA
Median mileage
38,600miles, 2 complaints with mileage
Recalls
12campaigns on record
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA crash rating
5 / 5stars overall, 4 rated versions
EPA fuel economy
25 mpgcombined, 2.0L 4-cyl RWD · 22 city / 31 hwy

Sources: NHTSA records for the 2021 Mercedes-Benz E350 (complaints, recalls, investigations), NHTSA crash tests, EPA fuel economy. Report an error

NHTSA recorded 13 consumer complaints for the 2021 Mercedes-Benz E350. The part named most often is electrical system, with 4 complaints (31% of the total), followed by engine (4) and back-over prevention (3). 2 of the complaints include a mileage, and 50% of those were filed for vehicles with under 50,000 miles; the median is 38,600 miles. Of all complaints, 1 a fire, according to the filers. NHTSA lists 12 recall campaigns and 214 technical service bulletins for this model year. Electrical system complaints overlap with 1 recall campaign and 98 technical service bulletins filed under the same part. Engine complaints overlap with 15 technical service bulletins filed under the same part.

This model year has fewer than 25 complaints on record, so the numbers below can change a lot with a few new reports.

Which parts are reported most

Complaints can name more than one part, so the counts add up to more than the total. Select a part to see its complaints, recalls and bulletins.

Example complaints

Electrical system: “FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to the ground and insurance has declared it a total loss. Car was in my driveway, was certainly a danger to me, to my house and to my neighbor's cars and house.”

NHTSA complaint #11629406, filed 2024-12

Engine: “Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.”

NHTSA complaint #11707258, filed 2025-12

Back-over prevention (rear camera): “I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.”

NHTSA complaint #11589422, filed 2024-05

Fuel system: “The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced. The vehicle was not repaired. The local dealer and manufacturer were notified of the failure and informed the contact that the VIN was not included in NHTSA Campaign Number: 23V445000 (Fuel System, Gasoline). The contact stated that the vehicle had experienced that failure listed in the recall. …”

NHTSA complaint #11567020, filed 2024-01, 53,200 miles

Mileage when problems were reported

50% of the 2 complaints with a mileage were filed for vehicles with under 50,000 miles; the middle half falls between 24,001 and 53,200 miles.

0%0–1050%10–250%25–5050%50–750%75–1000%100–1500%150+
Share of complaints by mileage when the problem was reported, in thousands of miles (2 complaints with mileage). Red bars: under 50,000 miles. Bucket widths differ. Median: 38,600 miles.

Complaints by year filed

Fewer than 15 complaints, too few for a reliable trend.

20232024520252026
Complaints by year the complaint was filed with NHTSA. Red bars: the last 3 full calendar years used for the trend. The current year (2026) is partial.

Crash test ratings

NHTSA's 5-Star Safety Ratings for the 2021 Mercedes-Benz E350. Frontal results are shown driver / passenger; rollover shows the star rating and NHTSA's estimated risk of rolling over in a single-vehicle crash.

VersionOverallFrontalSideSide poleRollover
E-Class · wagon 4WD★★★★★4 / 5555 · 9.7% risk
E-Class · sedan 4WD★★★★★4 / 5555 · 9.7% risk
E-Class · sedan RWD★★★★★4 / 5555 · 9.7% risk
E-Class · wagon RWD★★★★★4 / 5555 · 9.7% risk

Driver aids listed by NHTSA for the 2021 model year: forward collision warning standard, lane departure warning not available, automatic emergency braking optional.

Neighbouring years: 2020: same overall rating; 2022: same overall rating. A redesign between years can change both the car and the test.

Source: NHTSA New Car Assessment Program (5-Star Safety Ratings), nhtsa.gov/ratings.

Fuel economy and running cost

EPA ratings for each 2021 Mercedes-Benz E350 version. Annual fuel cost is the EPA's estimate at its current fuel prices for 15,000 miles a year (55% city driving).

VersionEngineTransmissionCityHwyComb.Fuel / yr
E350 RWD2.0L 4-cyl9-speed automatic223125$3,300
E350 4matic 4WD2.0L 4-cyl9-speed automatic223025$3,300

Source: U.S. EPA and Department of Energy, fueleconomy.gov. Ratings are for comparing vehicles; real-world mileage varies with driving and conditions.

Recalls and investigations

See all 12 recalls for the 2021 Mercedes-Benz E350 → · Check a VIN at nhtsa.gov/recalls

Technical service bulletins

TSBs are manufacturer notes to dealers about known repair procedures. They are not recalls and do not by themselves mean a vehicle has a fault. 214 on record; the latest 10 are shown.

See all 214 bulletins →

Other model years of the Mercedes-Benz E350

YearComplaintsMedian miRecallsCrash ★MPGScore (50 = typical)Trend
202459,6004———Too new
20236—3526—Too new
2022914,4033526—Not enough data
20211338,60012525—Not enough data
2020842,3636526—Not enough data
2017720,00005——Not enough data
20165138,212542328 · FewerFalling
20153125,00064236 · FewerRising
201427846,600842382 · MoreStable
201316444,5506—2354 · TypicalStable
201221769,7007—2257 · TypicalStable
201122359,2005—2050 · TypicalStable
201018459,9784—2153 · TypicalStable
20096481,5004—196 · FewerFalling
200817386,6884—1926 · FewerFalling
200735076,0005—19Not compared (before 2008)Falling
200640090,0004—20Not compared (before 2008)Falling
20051585,0000———Falling
200410135,0000———Not enough data
2003776,0000———Not enough data

All Mercedes-Benz E350 model years · Best and worst years by complaints

Frequently asked questions

How many NHTSA complaints does the 2021 Mercedes-Benz E350 have?

NHTSA recorded 13 consumer complaints for the 2021 Mercedes-Benz E350 as of Oct 30, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

What part of the 2021 Mercedes-Benz E350 is reported most often?

Electrical system is named most often, in 4 complaints (31% of the total), followed by engine with 4.

Has the 2021 Mercedes-Benz E350 been recalled?

NHTSA lists 12 recall campaigns for this model year. To check a specific vehicle, enter its VIN at nhtsa.gov/recalls.

How did the 2021 Mercedes-Benz E350 do in NHTSA crash tests?

NHTSA's 5-Star Safety Ratings give the 2021 Mercedes-Benz E350 5 out of 5 stars overall, across 4 rated versions (body style and drive). Ratings from different model years are only comparable when the vehicle was not redesigned in between.

What gas mileage does the 2021 Mercedes-Benz E350 get?

The EPA rates the 2021 Mercedes-Benz E350 (E350, 2.0L 4-cyl) at 25 mpg combined, 22 city and 31 highway, with an estimated annual fuel cost of $3,300 at 15,000 miles a year. Other engine and drive versions are rated differently.

At what mileage are problems with the 2021 Mercedes-Benz E350 reported?

Among the 2 complaints that include a mileage, the median is 38,600 miles and the middle half falls between 24,001 and 53,200 miles; 50% were filed for vehicles with under 50,000 miles.

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 30, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate. Crash ratings are from NHTSA’s New Car Assessment Program. Fuel economy is from the EPA and DOE (fueleconomy.gov).

Complaint counts come from NHTSA’s public complaint database; we count each complaint once. The source records for this vehicle are on nhtsa.gov. Scores and trends are our own summaries of that data, described in the methodology. This page is not legal, safety or repair advice: for a specific vehicle, check its VIN at nhtsa.gov/recalls and ask a qualified mechanic. See an error? Tell us.