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Mercedes-Benz E350Model year report

2022 Mercedes-Benz E350 Problems

Complaints
9filed with NHTSA
Median mileage
14,403miles, 1 complaints with mileage
Recalls
3campaigns on record
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.
NHTSA crash rating
5 / 5stars overall, 2 rated versions
EPA fuel economy
26 mpgcombined, 2.0L 4-cyl RWD · 23 city / 31 hwy

Sources: NHTSA records for the 2022 Mercedes-Benz E350 (complaints, recalls, investigations), NHTSA crash tests, EPA fuel economy. Report an error

NHTSA recorded 9 consumer complaints for the 2022 Mercedes-Benz E350. The part named most often is forward collision avoidance, with 3 complaints (33% of the total), followed by other or unknown (3) and electrical system (1). 1 of the complaints include a mileage, and 100% of those were filed for vehicles with under 50,000 miles; the median is 14,403 miles. NHTSA lists 3 recall campaigns and 152 technical service bulletins for this model year. Forward collision avoidance complaints overlap with 4 technical service bulletins filed under the same part. Other or unknown complaints overlap with 3 technical service bulletins filed under the same part.

This model year has fewer than 25 complaints on record, so the numbers below can change a lot with a few new reports.

Which parts are reported most

Complaints can name more than one part, so the counts add up to more than the total. Select a part to see its complaints, recalls and bulletins.

Example complaints

Forward collision avoidance: “2022 Mercedes-Benz E350 with Driver Assistance Package. Two incidents of uncommanded automatic braking with no vehicle ahead and no debris on the road: (1) October 7, 2026, 4:30 AM — Active Brake Assist braked automatically on a clear road in dark conditions; (2) second incident of the same kind, date unknown. No collision resulted, but sudden uncommanded braking in live traffic is a serious rear-end crash risk.”

NHTSA complaint #11770360, filed 2026-10

Other or unknown: “The panoramic sunroof exploded while inside the car without warning. Contacted the dealership/service center on Friday 9/15/2023, was told they have not received a memo regarding the panoramic sunroofs in the 2022 E350, however; this is a know problem. I was told that this is not covered of my warranty because they assume something had to hit the glass, provided evidence via my security camera that not fell and hit the glass. Even after this happened the warning system did not even go off to indicate there was a problem.”

NHTSA complaint #11545429, filed 2023-09

Fuel system: “The contact owns a 2022 Mercedes-Benz E350. The contact stated that on several occasions while driving at various speeds, the vehicle decelerated while the accelerator pedal was depressed. The contact was able to turn off and restart the vehicle. An unknown warning light was illuminated. The vehicle was taken to the dealer where it was diagnosed a fuel pump failure. The contact was informed that the fuel pump needed to be replaced. …”

NHTSA complaint #11540275, filed 2023-08, 14,403 miles

Mileage when problems were reported

100% of the 1 complaints with a mileage were filed for vehicles with under 50,000 miles; the middle half falls between 14,403 and 14,403 miles.

0%0–10100%10–250%25–500%50–750%75–1000%100–1500%150+
Share of complaints by mileage when the problem was reported, in thousands of miles (1 complaints with mileage). Red bars: under 50,000 miles. Bucket widths differ. Median: 14,403 miles.

Complaints by year filed

Fewer than 15 complaints, too few for a reliable trend.

202332024202520263
Complaints by year the complaint was filed with NHTSA. Red bars: the last 3 full calendar years used for the trend. The current year (2026) is partial.

Crash test ratings

NHTSA's 5-Star Safety Ratings for the 2022 Mercedes-Benz E350. Frontal results are shown driver / passenger; rollover shows the star rating and NHTSA's estimated risk of rolling over in a single-vehicle crash.

VersionOverallFrontalSideSide poleRollover
E-Class · sedan 4WD★★★★★4 / 5555 · 9.7% risk
E-Class · sedan RWD★★★★★4 / 5555 · 9.7% risk

Driver aids listed by NHTSA for the 2022 model year: forward collision warning standard, lane departure warning not available, automatic emergency braking not available.

Neighbouring years: 2021: same overall rating; 2023: same overall rating. A redesign between years can change both the car and the test.

Source: NHTSA New Car Assessment Program (5-Star Safety Ratings), nhtsa.gov/ratings.

Fuel economy and running cost

EPA ratings for each 2022 Mercedes-Benz E350 version. Annual fuel cost is the EPA's estimate at its current fuel prices for 15,000 miles a year (55% city driving).

VersionEngineTransmissionCityHwyComb.Fuel / yr
E350 RWD2.0L 4-cyl9-speed automatic233126$3,150
E350 4matic AWD2.0L 4-cyl9-speed automatic212924$3,400

Source: U.S. EPA and Department of Energy, fueleconomy.gov. Ratings are for comparing vehicles; real-world mileage varies with driving and conditions.

Recalls and investigations

Recall details for the 2022 Mercedes-Benz E350 → · Check a VIN at nhtsa.gov/recalls

Technical service bulletins

TSBs are manufacturer notes to dealers about known repair procedures. They are not recalls and do not by themselves mean a vehicle has a fault. 152 on record; the latest 10 are shown.

See all 152 bulletins →

Other model years of the Mercedes-Benz E350

YearComplaintsMedian miRecallsCrash ★MPGScore (50 = typical)Trend
202459,6004———Too new
20236—3526—Too new
2022914,4033526—Not enough data
20211338,60012525—Not enough data
2020842,3636526—Not enough data
2017720,00005——Not enough data
20165138,212542328 · FewerFalling
20153125,00064236 · FewerRising
201427846,600842382 · MoreStable
201316444,5506—2354 · TypicalStable
201221769,7007—2257 · TypicalStable
201122359,2005—2050 · TypicalStable
201018459,9784—2153 · TypicalStable
20096481,5004—196 · FewerFalling
200817386,6884—1926 · FewerFalling
200735076,0005—19Not compared (before 2008)Falling
200640090,0004—20Not compared (before 2008)Falling
20051585,0000———Falling
200410135,0000———Not enough data
2003776,0000———Not enough data

All Mercedes-Benz E350 model years · Best and worst years by complaints

Frequently asked questions

How many NHTSA complaints does the 2022 Mercedes-Benz E350 have?

NHTSA recorded 9 consumer complaints for the 2022 Mercedes-Benz E350 as of Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

What part of the 2022 Mercedes-Benz E350 is reported most often?

Forward collision avoidance is named most often, in 3 complaints (33% of the total), followed by other or unknown with 3.

Has the 2022 Mercedes-Benz E350 been recalled?

NHTSA lists 3 recall campaigns for this model year. To check a specific vehicle, enter its VIN at nhtsa.gov/recalls.

How did the 2022 Mercedes-Benz E350 do in NHTSA crash tests?

NHTSA's 5-Star Safety Ratings give the 2022 Mercedes-Benz E350 5 out of 5 stars overall, across 2 rated versions (body style and drive). Ratings from different model years are only comparable when the vehicle was not redesigned in between.

What gas mileage does the 2022 Mercedes-Benz E350 get?

The EPA rates the 2022 Mercedes-Benz E350 (E350, 2.0L 4-cyl) at 26 mpg combined, 23 city and 31 highway, with an estimated annual fuel cost of $3,150 at 15,000 miles a year. Other engine and drive versions are rated differently.

At what mileage are problems with the 2022 Mercedes-Benz E350 reported?

Among the 1 complaints that include a mileage, the median is 14,403 miles and the middle half falls between 14,403 and 14,403 miles; 100% were filed for vehicles with under 50,000 miles.

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate. Crash ratings are from NHTSA’s New Car Assessment Program. Fuel economy is from the EPA and DOE (fueleconomy.gov).

Complaint counts come from NHTSA’s public complaint database; we count each complaint once. The source records for this vehicle are on nhtsa.gov. Scores and trends are our own summaries of that data, described in the methodology. This page is not legal, safety or repair advice: for a specific vehicle, check its VIN at nhtsa.gov/recalls and ask a qualified mechanic. See an error? Tell us.