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Transmission and drivetrainPart report

2006 Ford E-350 Transmission and drivetrain Problems

Complaints
3about this part
Share
6%of 53 total for the year
Median mileage
12,584miles
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 3 complaints about the transmission and drivetrain of the 2006 Ford E-350, 6% of the 53 complaints for this model year. Where a mileage was given, the median is 12,584 miles. 1 of these say a crash was involved, according to the filers.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“Dt: the contact stated that while driving there was an acrid smell coming from the air-conditioning vents. The dealer diagnosed the problem to be an air compressor failure in the air-conditioning system. The contact has ten 2005, and 3, 2006 vehicles. All 13 had the alternators replaced by the dealer before the buses were put into service. There have been 3 alternator failures, 2 high pressure pump failures, 1 clutch fan failure and 5 vehicles with check engine light issues. Updated 8/15/2006 -”

NHTSA complaint #10163108, filed 2006-07, 16,832 miles

“2006 Ford econoline e350, transmission started shifting erratically causing him to lose control. The driver struck a guardrail, entered the roadway again and was struck by a semi-tractor trailer. Ohio traffic crash report# 10-0635-90. Updated 04/14/10”

NHTSA complaint #10321993, filed 2010-03

Related service bulletins

Transmission and drivetrain: other model years

YearComplaintsShare of year
2022214%
201718%
2016240%
2015229%
201416%
2012425%
2011316%
201016%
200825%
2007211%
200636%
200559%
2004511%
2001510%
200023%
199823%
199745%
199624%
199534%
1994510%
199325%
1992410%
199115%
198928%
198619%
1983120%

Other parts of the 2006 Ford E-350

Engine cooling
13 complaints
Steering
9 complaints
Brakes
7 complaints
Electrical system
7 complaints
Fuel system
7 complaints
Body and structure
5 complaints
Engine
4 complaints
Tires
4 complaints
Electronic stability control
2 complaints
Exterior lighting
2 complaints
Seat belts
2 complaints
Suspension
2 complaints

← All problems reported for the 2006 Ford E-350

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology