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Engine coolingPart report

2006 Ford E-350 Engine cooling Problems

Complaints
13about this part
Share
25%of 53 total for the year
Median mileage
39,900miles
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 13 complaints about the engine cooling of the 2006 Ford E-350, 25% of the 53 complaints for this model year. Where a mileage was given, the median is 39,900 miles. 1 of these say a crash was involved and 2 a fire, according to the filers.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“Failure of injectors and internal oil cooler LED to immediate engine shut down causing immediate loss of power steering, power brakes, etc. This happened on two separate occasions, (1 while driving on interstate during 8am morning traffic, 2 while towing a 5th wheel rv in heavy afternoon traffic in a construction zone with no shoulder available for me to get off highway). As I often pull rv's to the far west, it greatly concerns me as to what the outcome would be if this happens while on a 6% downgrade in the mountains. I have had three injector failures recently.”

NHTSA complaint #10210756, filed 2007-12, 39,900 miles

“Spark plug blow out on a 2006 Ford e350 5.4 liter engine. Causes fuel to spray out and fire to ignite. Thin aluminum head is not strong enough to hold spark plug in place. There are over 5 million web pages concerning this issue.”

NHTSA complaint #10383084, filed 2011-02, 61,333 miles

“Vehicle had a very bad engine oil leak. Sent to woolwine Ford for repair. They failed to repair problem. Sent vehicle to butch ostalet Ford. Ford authorized them to install a new short block and they did. This engine leaks in the same place as the original engine.”

NHTSA complaint #10180990, filed 2007-01, 16,655 miles

“Ford 6.0 diesel engines have issues in respect to the seals on the oil pumps for the injection system. It is not a question of if the seals will fail, it's when. When the seals fail, the engine will shut down completely leaving the driver without power steering or brakes. I have two (2) vehicles fail in traffic causing the drivers to attempt to exit the roadway without being hit by another vehicle. The issue seems to be related to the o-ring seals used through-out the injection system. …”

NHTSA complaint #10329140, filed 2010-05, 80,000 miles

“Dt: the contact stated that while driving there was an acrid smell coming from the air-conditioning vents. The dealer diagnosed the problem to be an air compressor failure in the air-conditioning system. The contact has ten 2005, and 3, 2006 vehicles. All 13 had the alternators replaced by the dealer before the buses were put into service. There have been 3 alternator failures, 2 high pressure pump failures, 1 clutch fan failure and 5 vehicles with check engine light issues. Updated 8/15/2006 -”

NHTSA complaint #10163108, filed 2006-07, 16,832 miles

Related service bulletins

Engine cooling: other model years

YearComplaintsShare of year
201318%
2009220%
200813%
2007317%
20061325%
20051629%
20041022%
2003613%
20021630%
20011427%
2000610%
19991217%
1998813%
19971519%
199636%
199546%
1994816%
1993716%
1992410%
1991211%
199029%
1989415%
198819%
1987321%
1986327%
1983120%

Other parts of the 2006 Ford E-350

Steering
9 complaints
Brakes
7 complaints
Electrical system
7 complaints
Fuel system
7 complaints
Body and structure
5 complaints
Engine
4 complaints
Tires
4 complaints
Transmission and drivetrain
3 complaints
Electronic stability control
2 complaints
Exterior lighting
2 complaints
Seat belts
2 complaints
Suspension
2 complaints

← All problems reported for the 2006 Ford E-350

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 27, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology