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Transmission and drivetrainPart report

2021 Mercedes-Benz Sprinter 2500 Transmission and drivetrain Problems

Complaints
5about this part
Share
11%of 45 total for the year
Median mileage
—not reported
Trend
Not enough dataFewer than 15 complaints, too few for a reliable trend.

NHTSA recorded 5 complaints about the transmission and drivetrain of the 2021 Mercedes-Benz Sprinter 2500, 11% of the 45 complaints for this model year. 1 recall campaign on record is filed under a similar system.

Fewer than 15 complaints name this part, so treat the figures as a rough indication only.

Example complaints

Selected from NHTSA records; personal details are removed. They are consumer reports, not findings.

“At altitudes of over 5,000’ MSL the vehicle will not move when shifted into Drive or Reverse. No response from gas pedal. Vehicle will randomly hesitate with zero or poor throttle response when driving creating an extreme safety hazard.”

NHTSA complaint #11485202, filed 2022-09

“CRITICAL SAFETY CONCERN: Vehicle shifts into NEUTRAL during normal start sequence, could roll over passengers. Component of concern: Electronic Wiper stalk shifter is easily shifted into NEUTRAL during normal start sequence. Problem encountered several times in our 2021 Mercedes Sprinter- the stalk shifter is located directly in front of the START/STOP ignition button. To start the vehicle, you must: 1) Press and hold the brake 2) Reach under the shifter and press the START/STOP button The problem is pressing the brake is also the safety interlock for shifting out of PARK. …”

NHTSA complaint #11683080, filed 2025-08

“The contact stated their company owns a 2021 Mercedes-Benz Sprinter 2500. The contact stated that the gear shifter was shifted into park(P) and the parking brake erroneously activated; however, the vehicle rolled forward as if the gear shifter was in drive(D). The contact depressed the brake pedal and made several attempts to put the vehicle in park(P). There were no warning lights illuminated. The contact was not sure if the vehicle had been taken to the dealer to be diagnosed or repaired. The manufacturer was not made aware of the failure. The failure mileage was unknown.”

NHTSA complaint #11493899, filed 2022-11

Related recalls

Related service bulletins

Transmission and drivetrain: other model years

YearComplaintsShare of year
2024217%
2023526%
202238%
2021511%
20201823%
20191421%
2018321%
201718%
201614%
201514%
201425%
201315%
201117%

Other parts of the 2021 Mercedes-Benz Sprinter 2500

Electrical system
9 complaints
Forward collision avoidance
9 complaints
Brakes
8 complaints
Lane departure
7 complaints
Other or unknown
6 complaints
Engine
5 complaints
Body and structure
4 complaints
Fuel system
3 complaints
Seats
3 complaints
Steering
3 complaints
Visibility (wipers, defrost, mirrors)
3 complaints
Air bags
2 complaints

← All problems reported for the 2021 Mercedes-Benz Sprinter 2500

About this data. Data from NHTSA (ODI) complaints, recalls, TSBs and investigations, updated Oct 31, 2026. Complaints are unverified consumer reports and may be duplicated or inaccurate.

To check a specific vehicle for open recalls, use its VIN at nhtsa.gov/recalls. Methodology